The Closure® Procedure - A Treatment That Works

   Clinical results indicate that the Closure procedure can be effective at closing the vein and significantly reducing patient symptoms. Patient Symptoms Reported at Follow-up1

Symptom	Pretreatment	6 Weeks	2 Years
Leg Pain Leg Fatigue Edema (swelling)	85% 85% 19%	6% 12% 8%	5% 5% 0%

   Prior to the Closure procedure, 85% of patients reported leg pain. After the Closure procedure, 94% of patients at six weeks and 95% of patients at two years, did not report residual leg pain.

Typical Cosmetic Results: Before and After the Closure Procedure2

Pre-treatment	Typical results 48 hours after the Closure procedure

Percent of Legs Without Varicose Veins at Follow-up

   The Closure procedure may be as effective as vein stripping in delaying the reappearance of varicose veins.

Treatment	1 Year	2 Years
Closure3 Vein Stripping4 Ligation4	88% 85% 86%	86% 75% 57%

1Weiss, R, et al. Controlled Radiogrequency Endovenous Occlusion Using a Unique Radiofrequency Catheter Under Duplex Guidance to Eliminate Saphenous Varicose Vein Reflux: A 2-Year Follow-up. Dermatol Surg 2002; 28:38-42.

2 Photos courtesy of Robert Merchant, M.D.

3 Data on File - VNUS Medical Technologies, Inc.

4Jones L et al.Neovascularisation is the principal cause of varicose vein recurrence: results of a randomized trial of stripping the long saphenous vein, Eur J Vasc Endovasc Surg, 1996; 12; 442-445